Table 1. Effects of forest product derived polysaccharides on inflammation and immune responses via the intestinal microbiota

Origin Compound (constitutional monosaccharides) Gut bacteria changed Biological effects References
Plants
Lycium barbarum Polysaccharides (arabinose, rhamnose, xylose, mannose, galactose, glucose) Lactobacillus acidophilus↑, Bifidobacterium longum↑, Akkermansia↑, Lactobacillus↑, Prevotellaceae↑, Proteobacteria↑, Firmicutes↑, Bacteroidetes↓ Transforming growth factor (TGF)-β↑, IL-6↑ in serum, sIgA↑ in the colon (Zhu et al., 2020)
Nelumbo nucifera Gaertn. Polysaccharides [(1→4)-α-D-glucan with α-D-glycopyranosyl moieties] Veillonellaceae↑, Negativicutes↑, Escherichia↑, Shigella↑, Bacteroidetes↑, Megamonas↑, Bifidobacterium↑, Firmicutes↓, Actinomycetes↓ Gut pH↓, SCFAs↑ (Guan et al., 2022)
Morus alba Linné leaves Polysaccharides (mannose, rhamnose, glucose, galactose, arabinose) Bacteroidetes↑, Firmicutes↓, ButyricimonasEubacterium SCFAs↑ (Chen et al., 2021)
Moringa oleifera Polysaccharides (β-gluco-pyranose, mannose) Muribaculaceae↑, Proteobacteria↓, Helicobacter↓, Stenotrophomonas Thymus index↑, spleen index↑, IL-6↓, TNF-α (Wen et al., 2022)
Dendrobium huoshanense Polysaccharides (glucose, xylose, galactose) Firmicutes/Bacteroidetes↓, Lactobacillus↑, Clostridium↓, Psychrobacter↓, Propionibacterium Cytokines↑, immune cells↑ (Xie et al., 2019)
Dendrobium aphyllum Polysaccharides (mannose, glucose) Porphyromonadaceae↑, Ruminococcacea↑, Erysipelotrichaceae↑ Gastrointestinal transit time↓, pH↓, fecal water-binding capability↑, SCFAs↑ (Liu et al., 2019)
Scutellaria baicalensis Georgi Polysaccharides (mannose, ribose, rhamnose, glucuronic acid, glucose, xylose, arabinose, fucose) Firmicutes↑, Bifidobacterium↑, Lactobacillus↑, Roseburia↑, Bacteroides↓, Proteobacteria↓ Staphylococcus Proinflammatory cytokines↓, SCFAs↑ (Cui et al., 2021)
Pueraria thomsonii Polysaccharides Parabacteroides↑, Prevotellaceae↑ Hepatic injury↓, steatosis↓, intestinal barrier integrity↓, inflammation↓ (Li et al., 2022a)
Mushrooms
Dictyophora indusiate Polysaccharides (glucose, mannose, galactose) Proteobacteria↓, Bacteroides↓, Gammaproteobacteria↓, Bacteroidaceae↓, Enterobacteriaceae↓, Lactobacillus Cytokine↓, anti-inflammatory cytokine↑, tight-junction proteins↑ (Kanwal et al., 2020)
Pleurotus eryngii Polysaccharides (glucose) Porphyromonadaceae↑, Rikenellaceae↑, Bacteroidaceae↑, Lactobacillaceae↑ Firmicutes↓, Bacteroidetes↑ pH↓, moisture content↑, SCFAs↑ (Ma et al., 2017)
Inonotus obliquus Polysaccharides (mannose, rhamnose, glucose, galactose, xylose, arabinose) Bacteroidetes↑, Firmicutes↓ Glutathione peroxidase↑, total antioxidant capacity↑, TNF-α↓, TGF β↓, lipase↓, trypsin↓ (Hu et al., 2017)
Mushrooms
Auricularia auricular-judae (Bull.) Polysaccharides (rhamnose, mannose, glucose, fucose, xylose, galactose) Deferribacteres↓, Actinobacteria↓, Ruminococcus sp.↓ Symptoms of colitis↓ (Zhao et al., 2020)
Flammuliana velutipes Polysaccharides (glucose, mannose, galactose) Lachnospiraceae↑, Ruminal butyrivibrio↑, Roseburia SCFAs↑ (Zhang et al., 2020)
Hericium erinaceus Polysaccharides Clostridiales↑, Akkermansia↑, Desulfovibrio Nitric oxide↓, malondialdehyde↓, total superoxide dismutase↓, myeloperoxidase↓ (Ren et al., 2018)
Lentinula edodes Polysaccharides Firmicutes/Bacteroidetes↓, Bacteroidia↑, Bacillus↓, Betaproteobacteria↓, Bacteroidaceae↑, Lactobacillaceae↓, Alcaligenaceae↓. Immune responses↑, cytokine↑ in peripheral blood. (Xu et al., 2015)
Ganoderma lucidum Polysaccharides Bacteroidetes↓, Firmictutes↑, Lactobacillales↑, Roseburia↑, Lachnospiraceae↑ Superoxide dismutase↑, total antioxidant activity↑, lipase↓, amylase↓, interferon γ↓, TNF-α (Li et al., 2016)
Phellinus linteus Polysaccharide extracts (glucose, arabinose, fucose, galactose, xylose) Roseburia↑, Prevotella↑, Ruminiclostridium-9↑, Lachnospiraceae↑, Blautia↑, Oscibacter↑, Clostridium↓, Escherichia↓, Bacteroidales↓ SCFAs↑, lipopolysaccharides↓ (Liu et al., 2020)
Please note that most of the results in the presented references are from studies performed on animal models, and additional experiments are required to determine if the results can apply to healthy individuals or humans.
↑: Increased, enhanced, promoted, or positively changed in terms of activity, expression, or concentration.
↓: Decreased, inhibited, repressed, reduced, or negatively changed in terms of activity, expression, or concentration.
IL: interleukin, sIgA: secretory immunoglobulin A, SCFAs: short-chain fatty acids, TNF: tumor necrosis factor.